TFSites

TF Sites

TF Sites is an easy-to-use computational toolkit to analyze enhancer sequences. Taking a variety of transcription factor (TF) reference data as input, TF Sites annotates and visualizes predicted sites within enhancers, reveals the effect of all possible mutations on TF-DNA interactions, and predicts which sites are altered across enhancer sequence variants.

Cite TF Sites: Solvason et al, 2025
Learn about TF Sites: Introductory Video

Where are predicted sites in enhancers?
Take me to the tool Take me to an Example
How do changes to enhancer sequence alter TF binding?
Take me to the tool Take me to an Example
What are sites that explain differential enhancer activity?
Take me to the tool Take me to an Example
What sites are altered across evolutionary time?
Take me to the tool Take me to an Example
What sites are altered in genetic variation?
Take me to the tool Take me to an Example

Got questions, or want to report a bug?       Terms and Conditions.
TFSites is not intended for use with Protected Health Information (PHI).    Hosted data is released under a Creative Commons v4 license.
Site developed under BSD 3-clause license.    Site version: v1.0.9.1.
We thank all of the scientists who contributed to the datasets from which we draw upon. We thank the Martha Bulyk lab and UniProbe for their work in generating and hosting protein binding microarray data. We thank those who put together the JASPAR and HOCOMOCO databases for organizing and hosting PWM motif data. We thank the Protein Data Base for providing an incredible interface for hosting x-ray crystallography data for TF-DNA structures.
© Regents of the University of California. Admin